Advanced Integrated Wet Lab and Computational Researcher, Surgery

UT Southwestern Medical Center
Dallas, TX
Job Description
Perform advanced, independent computational and systems biology research in support of high-impact translational and mechanistic studies in musculoskeletal biology, regeneration, tumor microenvironment biology, and aberrant mesenchymal cell fate. Collaborate directly with the Principal Investigator (PI) and multidisciplinary teams to design computational strategies that interrogate cellular heterogeneity, lineage trajectories, immune–stromal interactions, extracellular matrix remodeling, mechanotransductive signaling, and neurovascular regulation of tissue regeneration and tumor progression.

Requirements

  • Design and implement analysis pipelines for scRNA-seq, snATAC-seq, spatial transcriptomics, bulk RNA-seq, CyTOF, and proteomics datasets.
  • Perform trajectory inference, cell–cell communication modeling, ligand–receptor interaction analysis, gene regulatory network reconstruction, and pathway enrichment analyses.
  • Develop reproducible workflows using R, Python, and high-performance computing environments.
  • Develop machine learning models for disease prediction and therapeutic response.
  • Identify biomarkers, therapeutic targets, and signaling networks in regenerative and oncologic contexts.
  • Analyze longitudinal and multimodal datasets to model dynamic cellular state transitions.

Benefits

  • PPO medical plan
  • Paid Time Off
  • Retirement Programs through the Teacher Retirement System of Texas (TRS)
  • Paid Parental Leave Benefit
  • Wellness programs
  • Tuition Reimbursement
  • Public Service Loan Forgiveness (PSLF) Qualified Employer
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