Role OverviewThe Associate Director, Quantitative Systems Pharmacology will support a rapidly expanding clinical portfolio of promising RNAi therapeutics. The candidate will be well-versed in systems pharmacology, clinical pharmacology, PK and PD, and will critically evaluate and interpret data, conduct data analysis, and champion the application of QSP modeling and simulation approaches to answer key drug development questions.
What You Will Do
The candidate will strategize, formulate, and execute QSP modeling and simulation approaches for insights into dose selection, trial design, mechanistic understanding of the interaction between disease, biomarker, and treatment response, and predicting clinical outcomes. They will also build and utilize QSP models of biological or pathophysiological processes to understand disease pathways and the effect of treatment intervention.
Why It Might Be a Fit
The candidate will be a technical leader within the group, mentor team members, and establish and advance visibility and impact of QSP modeling internally and externally through publications in peer-reviewed journals and presentations at scientific meetings.
Requirements
- Ph.D (or equivalent) degree in applied mathematics, biomedical engineering, systems biology/pharmacology or related discipline
- At least 5 years of experience in pharmaceutical industry, consulting, or regulatory agency
- Track record of application of QSP modeling to impact drug development decisions
- Good understanding of systems biology, physiology, pharmacokinetics and pharmacodynamic principles
- Strong foundation of theory, principles and statistical aspects of modeling and simulation including differential equation based modeling and parameter estimation/optimization approaches
- Extensive hands-on experience with common QSP modeling platforms such as R, MATLAB, Simbiology etc.
- Experience in translating and summarizing QSP modeling outcomes into information understood by project teams
Benefits
- Comprehensive benefits including medical, dental, and vision coverage
- Life and disability insurance
- Lifestyle reimbursement program
- Flexible spending and health savings accounts
- 401(k) with a generous company match
- Paid time off
- Wellness days
- Holidays
- Two company-wide recharge breaks
- Generous family resources and leave
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