Director/Senior Director, Drug Metabolism & Pharmacokinetics (DMPK)

5AM Ventures
Boston, CA
Job Description
We are seeking a strategic, hands-on Director/Senior Director of Drug Metabolism & Pharmacokinetics (DMPK) to lead the design and execution of DMPK strategies across our small molecule discovery and development programs. This role is primarily focused on enabling high-quality decision-making across the portfolio: driving DMPK strategy from early discovery through human POC studies, guiding compound optimization, and ensuring robust characterization of pharmacokinetics, metabolism, and exposure-response relationships.

Requirements

  • Ph.D. in Pharmacokinetics, Pharmaceutical Sciences, Drug Metabolism, or related discipline
  • 12+ years of industry experience in DMPK within biotech or pharmaceutical settings
  • Demonstrated success advancing small molecule programs from discovery through IND
  • Deep expertise in ADME, human PK simulations, PK/PD modeling, and translational science
  • Experience working in or with early-stage companies, with comfort operating in resource-constrained, fast-paced environments
  • Strong track record of managing external CROs and consultants, and delivering high-quality data
  • Excellent communication skills, with the ability to influence cross-functional teams and leadership

Benefits

  • Performance bonuses
  • Equity participation
  • Comprehensive health benefits
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