Principal Scientist, Computational Protein Design

Flagship Pioneering
Cambridge, MA
Category Research
Job Description
Pioneering Intelligence, a Flagship Pioneering initiative, is seeking a Principal Scientist – Computational Protein Design to lead technical development in computational antibody design and developability optimization. This role involves collaborating with Pioneering Medicines to build foundational workflows for end-to-end antibody design, applying AI and computational tools to improve AI model performance. The position requires a blend of scientific and computational skills and a track record in antibody development and design.

Requirements

  • PhD in Biochemistry, Structural Biology, Biophysics, Protein Engineering, Computational Biology, Computer Science, or related field
  • 5+ years of relevant industry experience
  • Proven experience in the end-to-end design and optimization of antibodies
  • Strong track record in utilizing AI and computational methods for antibody engineering
  • Experience analyzing and interpreting antibody developability data
  • Experience leading projects in antibody discovery or biologics development
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