Principal Scientist, Computational Protein Design

Flagship Pioneering
Cambridge, MA
Category Research
Job Description
Flagship Pioneering is seeking a Principal Scientist – Computational Protein Design to lead technical development on computational antibody design. This role will involve AI-based design methods, optimizing antibody developability, and applying those methods to advance novel medicines. The successful candidate will work within a matrixed, cross-functional environment and collaborate with Pioneering Medicines and Flagship's scientific platforms.

Requirements

  • PhD in Biochemistry, Structural Biology, Biophysics, Protein Engineering, Computational Biology, Computer Science, or related field
  • 5+ years of relevant industry experience
  • Proven experience in end-to-end antibody design and optimization
  • Strong track record in AI and computational methods
  • Experience analyzing and interpreting antibody developability data
  • Experience leading projects in antibody discovery or biologics development
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