Role OverviewWe are seeking a highly motivated Scientist to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role is central to our in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies.
What You Will Do
Design and execute in vitro CAR-T functional assays, perform comprehensive phenotypic analysis of T cell differentiation, activation, and memory subsets, evaluate CAR-T cell trafficking and tumor infiltration in vivo using flow cytometry and immunohistochemistry.
Why It Might Be a Fit
The ideal candidate holds a PhD in Immunology, Immuno-Oncology, or a closely related discipline, with up to 3 years of postdoctoral experience. You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.
Requirements
- A scientist in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field.
- Primary human T cell isolation, activation, lentiviral transduction, and expansion is required.
- Multicolor flow cytometry: panel design, data acquisition (e.g., Attune, Novocyte, Cytek Aurora), and analysis (FlowJo).
- Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot.
- Experience with humanized mouse models for in vivo CAR-T evaluation.
- Proficiency in CAR-T cell trafficking studies: IHC/IF of tumor sections, in vivo imaging.
- Familiarity with gene editing tools (CRISPR/Cas9) for cell engineering.
- Experience with in vitro Organoid cancer model establishment and expansion.
- Experience in solid tumor indications (e.g., lung, gastric, or other refractory cancers).
- Contributions to innovation in cell therapy (publications, patents, or conference presentations).
Benefits
- Medical, dental, and vision insurance
- 401(k) retirement plan with a company match
- Eight (8) weeks of paid parental leave
- Paid time off policy (vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays)
- Flexible spending and health savings accounts
- Life and AD&D insurance
- Short- and long-term disability coverage
- Legal assistance
- Supplemental plans (pet, critical illness, accident, and hospital indemnity insurance)
- Voluntary commuter benefits
- Family planning and care resources
- Well-being initiatives
- Peer-to-peer recognition programs
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