Senior Director, Pharmacokinetics, Dynamics, Metabolism and Bioanalysis, Protein Therapeutics

The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Senior Director to contribute to our Company's protein therapeutic efforts from discovery through to candidate selection and into FIH trials. This position will be based at our research labs in Boston, MA. This senior leader will provide scientific and operational oversight for PK/PD and bioanalytical activities related to protein therapeutic drug candidates, including bispecific antibodies, antibody-drug conjugates (ADCs), fusion proteins, and emerging modalities.

What You Will Do

Oversee the design and interpretation of pharmacokinetic, immunogenicity and ADME studies for protein therapeutics across multiple disease indications and therapeutic areas. Mentor and manage a team of high performing PDMB scientists and managers (multi-tiered organization) supporting protein therapeutic optimization (PK, distribution, translational strategy) and discovery bioanalytics (ligand binding assays, mass spectrometry).

Why It Might Be a Fit

Strong leadership, interpersonal, communication, problem solving and collaborative qualities to deliver high quality results in a fast-paced environment. Experience contributing to development and execution of translational PK/PD efficacy relationships, human dose predictions and other useful quantitative pharmacology applications in a discovery setting.

Requirements

• Ph.D (with 7+ years relevant experience) degree in biochemistry, pharmacology, pharmaceutical sciences, protein engineering, molecular biology, bioengineering, or related STEM field
• Demonstrated experience leading protein therapeutic discovery efforts as a group leader or independent project-team representative within a highly collaborative environment
• Strong understanding of protein therapeutic bioanalytical, ADME, FcRn biology, target-mediated drug disposition (TMDD) and immunogenicity concepts for modalities such as monoclonal antibodies or engineered bispecifics
• Proven track record of managing scientists and leading cross-functional teams in a drug discovery or development setting
• Experience contributing to development and execution of translational PK/PD efficacy relationships, human dose predictions and other useful quantitative pharmacology applications in a discovery setting

Benefits

• medical, dental, vision healthcare and other insurance benefits (for employee and family)
• retirement benefits, including 401(k)
• paid holidays, vacation, and compassionate and sick days