Senior Manufacturing Systems Engineer – Manufacturing Systems and Integrated

Lifelancer
Thousand Oaks, CA
Job Description
Join Amgen's Mission of Serving Patients as a Senior Manufacturing Systems Engineer – Manufacturing Systems and Integrated Technologies. You will be part of our Clinical and Commercial Manufacturing Operations Technology team, driving the operation, refinement, and integration of cutting-edge manufacturing applications. You will manage the MES platform and associated integrations for the ATO site, work closely with the Global Instrument Data Acquisition (IDA) team to drive a Global MES Standardization effort across all Amgen manufacturing locations, and optimize manufacturing systems, enhance data integrity, and promote consistency and efficiency across Amgen's worldwide network.

Requirements

  • Support key TCT manufacturing systems by driving operational stability and continuous improvements across Building 7, B20, B23, and the ATO site.
  • Manage key system integrations, both existing and new, to streamline manufacturing operations.
  • Champion business process improvements and support strategic digital initiatives by leveraging established platforms, city plan technology, and artificial intelligence applications.
  • Provide on-call support, including after-hours escalations and troubleshooting for operations technology application issues, aligned with 24x7 manufacturing requirements at the ATO site.
  • Lead major incident and problem investigations, including root cause analysis, deviation investigations, corrective actions, and 5-why analysis.
  • Ensure compliance by maintaining and updating inspection readiness for critical applications, including inspection playbooks, periodic assessments for data integrity, security, and system compliance, and SDLC validation and testing.
  • Support regulatory inspections by providing data, delivering presentations on site systems and technology processes, and collaborating with subject matter experts as needed.
  • Lead initiatives to introduce Industry 4.0 technologies to improve manufacturing efficiency and capacity.
  • Lead and train team members to support operational excellence and develop multi-system competencies.
  • Support and lead CMDB updates and system health, ensuring accurate and up-to-date configuration data in partnership with service owners and managers.
  • Support the assessment of impactful changes during weekly ATO Change Advisory Board (CAB) meetings.
  • Support Amgen's cyber resiliency efforts, including Sentinels and ECR Network initiatives.
  • Provide on-site, client-facing support at the ATO site up to five days per week, based on business needs.

Benefits

  • Comprehensive employee benefits package
  • Discretionary annual bonus program
  • Stock-based long-term incentives
  • Award-winning time-off plans
  • Flexible work models
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