Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease Genomics

Sanofi
Cambridge, MA
Category Research
Job Description
Role Overview

Join Sanofi's Target, Disease and Systems Biology (TDSB) team and become a key contributor to our Disease Genetics and Genomics cluster. In this role, you will sit at the intersection of real-world evidence generation and disease genomics, leveraging large-scale electronic health records (EHRs) and population biobanks to transform how we understand disease trajectories and evaluate indication expansion opportunities.

What You Will Do

Develop and apply cutting-edge EHR-based methods, including foundation models and classical statistical approaches, to generate real-world evidence at scale to understand disease trajectories. Define rigorously curated disease cohorts and progression endpoints to support target trial emulation and genomic analyses.

Why It Might Be a Fit

Genuine enthusiasm for working in an agile, fast-paced team environment where priorities evolve rapidly. Impact-oriented mindset with a strong drive to see scientific work translate into real R&D decisions.

Requirements

  • Ph.D. in Biomedical Informatics, Epidemiology, Computational Biology, Human Genetics, or a related field
  • 4+ years of post-PhD experience, preferably in the biopharma or biotech industry
  • Excellent knowledge of and hands-on experience working with longitudinal EHR datasets and OMOP common data models
  • Knowledge of target trial emulation methods and causal inference frameworks applied to observational data
  • Familiarity with GWAS methodology and population-scale genomic analyses
  • Good knowledge of diseases and medical practices, with the ability to engage meaningfully with clinical and disease area experts
  • Strong coding skills and demonstrated experience leveraging AI-assisted coding tools such as Cursor or Claude Code to accelerate scientific workflows
  • Excellent communication skills, with the ability to present complex analytical findings clearly to both scientific and non-scientific stakeholders, and to influence strategic decisions

Benefits

  • High-quality healthcare
  • Prevention and wellness programs
  • At least 14 weeks' gender-neutral parental leave
  • Thoughtful, well-crafted rewards package
  • Endless opportunities to grow your talent and drive your career
  • Discovery of extraordinary
]]>