Role OverviewThis position is for the Division of Genetic and Genomic Medicine within the Department of Pediatrics. The Research Technician IV will support preclinical therapeutic development for PDHA1-related pyruvate dehydrogenase complex deficiency (PDCD), a mitochondrial disorder of carbohydrate oxidation associated with significant morbidity and mortality. The position requires independent experimental execution, troubleshooting of complex protocols, and close collaboration with multidisciplinary teams in computational chemistry, medicinal chemistry, mitochondrial biology, and translational neuroscience.
What You Will Do
Responsibilities include culturing and maintaining genotype-defined cellular models, conducting biochemical, molecular biology, and pharmacology experiments, performing enzyme activity, metabolic flux, and mitochondrial function assays, and contributing to manuscript and grant preparation.
Why It Might Be a Fit
The successful candidate will be a collaborative, detail-oriented, and highly motivated individual who is eager to learn, capable of working independently, and enthusiastic about contributing to a multidisciplinary research program spanning drug discovery, cellular neuroscience, mitochondrial biology, and translational animal studies.
Requirements
- Bachelor's degree in biology, biochemistry, neuroscience, pharmacology, or a related field
- At least three years of relevant research experience
- Prior experience with mammalian cell culture, molecular biology, metabolic assays, and/or mouse models
- Strong organizational, analytical, and communication skills
Benefits
- PA Child Abuse History Clearance
- PA State Police Criminal Record Check
- FBI Criminal Record Check
- Current TB test
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