VP, Head of Preclinical Development

Legend Biotech is a clinical-stage biotech company developing cell therapies for hematological malignancies, solid tumors, and autoimmune diseases. We are seeking an exceptional scientist-leader to serve as Vice President, Head of Preclinical Development. This is a senior, externally visible leadership role accountable for the full preclinical development program across in vitro pharmacology, in vivo pharmacology, and toxicology for all pipeline compounds globally.

What You Will Do

Define and execute the preclinical development strategy across all pipeline programs globally from candidate nomination through IND-enabling studies. Serve as the internal scientific authority on in vitro pharmacology, in vivo pharmacology, and toxicology.

Why It Might Be a Fit

The person will build and lead a high-performing, integrated team, set scientific standards for the organization, and serve as the internal authority and external face for preclinical science across regulatory, partnership, and publication contexts.

Requirements

• PhD in pharmacology, toxicology, immunology, cell biology, or a closely related discipline.
• Minimum 15 years of progressive experience in preclinical drug development, with at least 5 years in a senior leadership role with direct accountability for IND-enabling programs.
• Deep expertise in at least two of the three core functions (in vitro pharmacology, in vivo pharmacology, toxicology), with working knowledge of the third.
• Demonstrated experience designing, overseeing, and interpreting GLP toxicology studies (repeat-dose NHP or rodent, safety pharmacology, genotoxicity) in support of IND filing.
• Experience in cell therapy, gene therapy, or advanced therapy development.
• Track record of successful IND submissions with clear accountability for the nonclinical pharmacology and toxicology sections.
• Experience managing CRO relationships for outsourced preclinical and GLP studies, including vendor qualification, protocol development, monitoring, and report review.
• Proven ability to lead, mentor, and build high-performing scientific teams in a fast-paced biotech environment.

Benefits

• Medical, dental, and vision insurance
• 401(k) retirement plan with a company match that vests fully on day one
• Eight (8) weeks of paid parental leave after just three (3) months of employment
• Paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
• Flexible spending and health savings accounts
• Life and AD&D insurance
• Short- and long-term disability coverage
• Legal assistance
• Supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
• Voluntary commuter benefits
• Family planning and care resources
• Well-being initiatives
• Peer-to-peer recognition programs